By Weiming Xia, Huaxi Xu
Within the look for a good remedy for Alzheimer's ailment, APP is a special version protein that illustrates the big choice of simple and complex characterization recommendations on hand.
Exploring a number of organic concepts to explain the constitution and serve as of this transmembrane protein, this article offers every one procedure with specified, step by step protocols to accomplish reproducible effects and supply a framework for learning different membrane proteins.
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Extra info for Amyloid precursor protein : a practical approach
Heparin oligosaccharides that pass the blood–brain barrier inhibit beta-amyloid precursor protein secretion and heparin binding to beta-amyloid peptide. J. Neurochem. 70, 736, 1998. 24. Rossjohn, J. et al. Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nature Struct. Biol. 6, 327, 1999. 25. Hilbich, C. et al. Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11. J. Biol. Chem.
Presumably, the growth-promoting activity of APP is expressed after it is released from membranes through the action of secretases. In conclusion, the structural similarities to some growth factors in concert with the known growth promoting properties of APP and its N-terminal domain led to the conclusion that GFD can be classified as a new member of the cysteine-rich growth factor superfamily. C. P. M. P. is a NHMRC Senior Principal Research Fellow. REFERENCES 1. Kang, J. et al. The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor.
4 It has been suggested that the FAD mutations may interfere with the possible dimerization of APP that leads to signal transduction, as may be the case with other cell surface receptors. The APP cytoplasmic domain binds to a number of proteins consistent with the possibility that APP functions as a receptor involved in signal transduction. 12,13 The antibody is presumably mimicking the action of a still-to-be-identified physiological ligand. 14 In summary, current knowledge suggests APP is a potential Go-coupled receptor with ligand-regulated function, although the physiological roles of APP remain to be established.
Amyloid precursor protein : a practical approach by Weiming Xia, Huaxi Xu