references

Market Expertise
Drug Discovery and Development Market

  • Cell Biology Market (Biochemical and Cellular Assays)
  • High Throughput Screening Market
  • Genomics Market (Sequencing | Microarrays | Diagnostics)
  • Proteomics Market
  • Laboratory Supplies Market

Medical Diagnostics Market

  • Point of Care Diagnostics Market
  • Molecular Diagnostics Market

Technical Expertise
Pharmeceutical and Medical Industry

  • Good Manufacturing Procedures (GMP)
  • Standard Operating Procedures (SOP’s)
  • FDA regulations
  • CFR Part 11 Compliance
  • Organic Synthesis
  • Biocatalysis and Biotransformations
  • Microbiology
  • DNA / RNA Synthesis
  • Sequencing
  • Protein Microarray and DNA Microarray Screening
  • Electrophysiology
  • Molecular Assays Development
  • Chromatography
  • Spectrophotometry
  • Electrophoresis
  • Radiolabelling
  • Molecular Biology (Cloning, Gene Expression)
  • Analytical Instrumentation (LC-MS, NMR, GC, CE, HPLC, robotic handlers, UV-platereaders)

Semiconductor and Consumer Electronics Industry

  • MEMS/Precision Etching Technology
  • Ferroelectric Thin Film Deposition Technology
  • Acousto-Optic Technology
  • Ultrasonic Separation Technology
  • Wireless Technology
  • Substrate and Mounting Technology

Publications
(Main Contributor is First Author)

  1. Daniel Yazbeck; Martinez, C.A. ; Hu, S.; Tao, J. Challenges in the Development of an Efficient Enzymatic Process in the Pharmaceutical Industry. Tetrahedron Asymmetry, 2004, 15, 2757-2763.
  2. Daniel Yazbeck; Tao, J.; Martinez, C. A.; Kline, B. J.; Hu, S. Automated Enzyme Screening Methods for the Preparation of Enantiopure Pharmaceutical Intermediates. Adv. Synth. Catal . 2003 , 345 , 524-532.
  3. Daniel Yazbeck ; Durao, P. J.; Xie, Z.; Tao, J. A High Throughput Metal Ion Based Methods for Nitrilase Screening, J. Mol. Cat. B , 2006, 39, 156-159 (special issue).
  4. Daniel Yazbeck ; Derrick, A.; Panesar, M.; Deese, A.; Gujral, A.; Tao, J. Enzymatic Hydrolysis of Racemic and Cis/Trans Ethyl Bicyclo[3.2.0]hept-6-ylidene-acetate: Solvent Effect and NMR Study, Org. Process. Res. Dev. , 2006 , 10 (3), 655 -660.
  5. Rossi, F., Daniel Yazbeck, et. al. Process Research and Development and Scale-up of a 4,4-Difluoro-3,3-dimethylproline Derivative. Org. Process. Res. Dev., 2008, 12, 322–338
  6. Xie, J.; Feng, J.; Garcia, E.; Bernett, M.; Daniel Yazbeck ; Tao, J. Cloning and Optimization of a Nitrilase for the Synthesis of (3S)-3-Cyano-5-methyl Hexanoic Acid, J. Mol. Cat. B, 2006.
  7. Hu, S.; Martinez , C.; Kline,B.; Daniel Yazbeck ; Tao, J. Efficient and Scalable Enzymatic Process for the Production of (2S)-4,4-Difluoro-3,3-dimethyl-N-Boc-proline, a Key Intermediate in the Synthesis of HIV Protease Inhibitors, Org. Process. Res. Dev., 2006, ASAP 2006:239222 (special issue).
  8. Lijian Chen, Young Mi Kim, David J. Kucera, Katheryn E. Harrison, Sogole Bahmanyar, Jill M. Scott, and Daniel Yazbeck. Fluorination-Free Synthesis of a 4,4-Difluoro-3,3-Dimethylproline Derivative. J. Org. Chem. 2006, 5 (3) .
  9. Hu, S., Tat, D., Martinez , C., Daniel Yazbeck , Tao, J. An Efficient and Practical Chemoenzymatic Preparation of Optically Active Secondary Amines. Organic Letters, 2005 , 7 , 4329-4331.
  10. Martinez , C.A. , Daniel Yazbeck , Tao, J. An Efficient Enzymatic Preparation of Rhinovirus Protease Inhibitor Intermediates. Tetrahedron. 2003 , 60 , 759-764.
  11. Daniel Yazbeck , Damha M.J. Molecular Requirements for degradation of a modified sense RNA strand by Escherichia coli Ribonuclease H1. Nucleic Acid Research. 2002, 30, 3015-2025.
  12. Daniel Yazbeck. Molecular Requirements for Degradation of RNA in DNA/RNA Hybrids by RNase H. MSc. Thesis, McGill University, Montreal, Canada, 2001.
  13. Daniel Yazbeck; Derrick, A.M. Resolution of racemic cis/trans ( 1R,5R)-Ethyl bicyclo[3.2.0]hept-6-ylideneacetate using Candida Antartica Lipase B. Industrial Biotransformations, Wiley-VCH, 2nd edition, 2005.

Patents
(Authorship in Alphabetical Order)

  1. Hu, S., Martinez, C., Tao, J., Yazbeck, Daniel. Methods for the Preparation of Stereoisomerically Enriched Amines. 2005 . WO 2005/054186 (world patent).
  2. Hu, S., Martinez, C., Tao, J., Yazbeck, Daniel. Efficient Microbial Preparation of Capravirine Metabolites M4 and M5. 2005 . US 2005/0043361A1.
  3. Matthews, C., Mitchell, M., Scott, R., Yazbeck, Daniel. Method For the Preparation of HCV Polymerase Inhibitors, 2004 , PC32421 PROV.
  4. Derrick, A., Yazbeck, Daniel. Intermediates In The Preparation of Therapeutic Fused Bicyclic Amino Acids, 2003 , PC025386PGS (U.S. Application Serial No.: 10/677,83)
  5. Chen, L, Borer, B., Kline, B., Lee, S. Michell, M., Martinez, C., Sakata, S., O’Neill-Slawecki, S., Tao, Junhua, Yazbeck, Daniel. Preparation of AG7404 Chiral Intermediates. 2003, PC25397.
  6. Hu, Shanghui, Martinez , C., Tao, J., Tat, D., Yazbeck, Daniel. An Efficient Preparation of Enatiopure Secondary Amines by a Protease Catalyzed Kinetic Resolution. 2003, PC25652.